Guides!

Simplemining OS guides - https://simplemining.net/

Motherboards

Asus B250 Mining Expert

Advanced Mode (F7)
Tool - Asus EZ Flash Utility - Via Internet (Update Bios)
Boot - CSM - Launch CSM - Enabled
Boot - Fast boot - disabled
Boot - Secure boot - Other OS
Advanced - mining mode - Enabled
Advanced - System agent Config - Primary Display - Graphics - CPU
Advanced - System agent Config - Primary Display - iGPU Multi-monitor - Enabled
Advanced - System agent Config - DMI/OPI conf - DMI Max Link speed - GEN 2 / Auto
Advanced - System agent Config - PEG port conf - PCIEX16.1 Link speed - GEN 2 / Auto
Advanced - PCH Config - PCI express config - GEN 2 / Auto
Advanced - Onboard devices config - HD Audio controller - Disabled
Advanced - APM config - Restore AC Power Loss - Power ON
Exit - Save Changes & Reset - OK

Most GPUs want Link speed Gen 2 - but you may need to use Auto for some newer cards like Nvidia 1660